P21 activated kinase signaling in cancer
CK Rane, A Minden - Seminars in cancer biology, 2019 - Elsevier
… Conversely, PAK4 depletion in invasive melanoma cells was … , adenomatous polyposis coli
(APC), casein kinase 1 (CK1), … suggests that PAK4 induced tumorigenesis may be mediated …
(APC), casein kinase 1 (CK1), … suggests that PAK4 induced tumorigenesis may be mediated …
The trilogy of P21 activated kinase, autophagy and immune evasion in pancreatic ductal adenocarcinoma
… in PDA tumorigenesis and P21-activated kinases (PAKs) are … Priming and activation of
antigen-presenting cells (APC) and … T cell depletion did not affect tumour growth in a PDA mouse …
antigen-presenting cells (APC) and … T cell depletion did not affect tumour growth in a PDA mouse …
[HTML][HTML] Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells
L Chen, S Bi, J Hou, Z Zhao, C Wang, S Xie - Cell Communication and …, 2019 - Springer
… , depletion of active PAK1 up-regulates the immune system of APC ∆14/+ mice and suppresses
intestinal … We next determined whether knockdown of PAK1 inhibits the tumorigenicity in …
intestinal … We next determined whether knockdown of PAK1 inhibits the tumorigenicity in …
[HTML][HTML] P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer
D Yao, C Li, MSR Rajoka, Z He, J Huang, J Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
… investigated by using gene knockout mouse models, with the … that PAK1 inhibition impeded
carcinogenesis in several … targeting PAK1 inhibition and cell cycle destruction would reap …
carcinogenesis in several … targeting PAK1 inhibition and cell cycle destruction would reap …
[HTML][HTML] P-21 activated kinases in liver disorders
… The p21 Activated Kinases (PAKs) are serine threonine kinases and play important … Depletion
of PAK1 enhanced the immune system and inhibited intestinal tumorigenesis in a mouse …
of PAK1 enhanced the immune system and inhibited intestinal tumorigenesis in a mouse …
p21-Activated kinases as promising therapeutic targets in hematological malignancies
A Wu, X Jiang - Leukemia, 2022 - nature.com
… In endothelial cells, depletion of PAK2 in adult mice … -7 reduced PAK1 levels and inhibited
tumorigenic potential [37]. … in the anti-tumor immune response has recently been reported by …
tumorigenic potential [37]. … in the anti-tumor immune response has recently been reported by …
Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis
K Okumura, M Saito, Y Yoshizawa, Y Ito, E Isogai… - Oncogene, 2020 - nature.com
… The threonine/serine kinase P21-activated kinase 1 (PAK1) … to skin carcinogenesis, we
generated F 1 mice by crossing a … depletion of epidermal stem cells, thereby inhibiting tumors. …
generated F 1 mice by crossing a … depletion of epidermal stem cells, thereby inhibiting tumors. …
[HTML][HTML] ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1
K Wang, X Qiu, Z Zhang, H Xu, Y Tan, R Su… - Cell Communication and …, 2023 - Springer
… on embryonic development and various cellular activities [14]. ATRA exerts these effects by
… immune system activation to inhibit intestinal tumorigenesis in a mouse model of intestinal …
… immune system activation to inhibit intestinal tumorigenesis in a mouse model of intestinal …
[HTML][HTML] Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer
… active in cells and mice, and while some inhibitors have entered … PAK1 with the immune
response to intestinal tumors [170]. … to inhibit PCa by phosphorylating the AR and tumorigenic E3 …
response to intestinal tumors [170]. … to inhibit PCa by phosphorylating the AR and tumorigenic E3 …
Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties
M Shahinozzaman, B Basak, R Emran, P Rozario… - Fitoterapia, 2020 - Elsevier
… arrest, and the inhibition of p21-activated kinase 1 (PAK1), a … [50] induced pulmonary
carcinogenesis in male ddY mice by … roles in the destruction of tissues and in inflammatory bowel …
carcinogenesis in male ddY mice by … roles in the destruction of tissues and in inflammatory bowel …